TY  - JOUR
TI  - SWISS-MODEL: homology modelling of protein structures and complexes
AU  - Andrew Waterhouse
AU  - Martino Bertoni
AU  - Stefan Bienert
AU  - Gabriel Studer
AU  - Gerardo Tauriello
AU  - Rafal Gumienny
AU  - Florian Heer
AU  - Tjaart de Beer
AU  - Christine Rempfer
AU  - Lorenza Bordoli
AU  - Rosalba Lepore
AU  - Torsten Schwede
PY  - 2018
JO  - Nucleic Acids Research
DO  - 10.1093/nar/gky427
UR  - https://doi.org/10.1093/nar/gky427
AB  - Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated workflows and servers simplify and streamline the homology modelling process, also allowing users without a specific computational expertise to generate reliable protein models and have easy access to modelling results, their visualization and interpretation. Here, we present an update to the SWISS-MODEL server, which pioneered the field of automated modelling 25 years ago and been continuously further developed. Recently, its functionality has been extended to the modelling of homo- and heteromeric complexes. Starting from the amino acid sequences of the interacting proteins, both the stoichiometry and the overall structure of the complex are inferred by homology modelling. Other major improvements include the implementation of a new modelling engine, ProMod3 and the introduction a new local model quality estimation method, QMEANDisCo. SWISS-MODEL is freely available at https://swissmodel.expasy.org.
ER  -