TY - JOUR TI - Marginal Structural Models and Causal Inference in Epidemiology AU - James M. Robins AU - Miguel A. HernĂ¡n AU - Babette Brumback PY - 2000 JO - Epidemiology DO - 10.1097/00001648-200009000-00011 UR - https://doi.org/10.1097/00001648-200009000-00011 AB - In observational studies with exposures or treatments that vary over time, standard approaches for adjustment of confounding are biased when there exist time-dependent confounders that are also affected by previous treatment. This paper introduces marginal structural models, a new class of causal models that allow for improved adjustment of confounding in those situations. The parameters of a marginal structural model can be consistently estimated using a new class of estimators, the inverse-probability-of-treatment weighted estimators. ER -