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Olabisi Onabanjo University
NG
4 researchers0 verified5 linked papers4,866 indexed citations
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Public research profiles associated with Olabisi Onabanjo University.
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2019 · JAMA Oncology · 2,690 citations
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017
Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs). Conclusions and Relevance The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
2021 · JAMA Oncology · 2,074 citations
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
2024 · Informatics and Health · 56 citations
Nursing in the Digital Age: Harnessing telemedicine for enhanced patient care
Telemedicine has emerged as a transformative force in contemporary healthcare, reshaping nursing practice across various specialties. This narrative review explored the role, challenges, and ethical considerations associated with telemedicine in nursing practice. Also, it emphasizes telemedicine’s impact on patient care, the evolution of nursing workflows, and future directions for implementation. A comprehensive narrative review was conducted, drawing upon primary research articles, systematic reviews, and policy documents published between 2010 and 2023. The search was carried out using electronic databases, including PubMed, ScienceDirect, CINAHL, and Google Scholar, employing keywords such as "telemedicine," "nursing practice," "patient care," and "ethical considerations." Eligible studies were critically appraised for relevance and rigor. Data synthesis included the identification of key themes, trends, and exemplary instances of telemedicine utilization in nursing practice. The review revealed a multifaceted role of telemedicine in nursing practice. Teletriage and remote patient monitoring were instrumental in reducing emergency department overcrowding and improving patient triage accuracy. Teleconsultations and virtual visits facilitated patient-provider interactions, while telepsychiatry addressed the growing demand for mental health support. Tele-education emerged as a vital tool for ongoing professional development among nurses. Moreover, telemedicine effectively reached rural and underserved populations, addressing healthcare disparities. Ethical considerations, such as patient privacy, informed consent, and data security, emerged as significant challenges in telemedicine. As telemedicine continues to evolve, nurses should remain adaptable, actively engaging with emerging technologies and interdisciplinary teams. Furthermore, healthcare organizations, policymakers, and nursing associations/regulatory bodies should collaborate to establish clear ethical and legal guidelines. These efforts will ensure the continued growth of telemedicine in nursing practice, ultimately enhancing patient outcomes and expanding access to quality healthcare services. • Telemedicine correlates with improved patient outcomes and higher satisfaction rates. • Nurses are pivotal in teletriage and remote patient monitoring initiatives. • Teleconsultations streamline care delivery, enhancing efficiency and accessibility. • Telepsychiatry bridges gaps in mental health services, catering to remote patients. • Teleeducation empowers nurses through accessible and flexible professional development.
2021 · Bioinformatics and Biology Insights · 28 citations
Anticancer Potential of <i>Moringa oleifera</i> on BRCA-1 Gene: Systems Biology
Breast cancer has consistently been a global challenge that is prevalent among women. There is a continuous increase in the high number of women mortality rates because of breast cancer and affecting nations at all modernization levels. Women with high-risk factors, including hereditary, obesity, and menopause, have the possibility of developing breast cancer growth. With the advent of radiotherapy, chemotherapy, hormone therapy, and surgery in breast cancer treatment, breast cancer survivors have increased. Also, the design and development of drugs targeting therapeutic enzymes effectively treat the tumour cells early. However, long-term use of anticancer drugs has been linked to severe side effects. This research aims to develop potential drug candidates from Moringa oleifera, which could serve as anticancer agents. In silico analysis using Schrödinger Molecular Drug Discovery Suite and SWISS ADME was employed to determine the therapeutic potential of phytochemicals from M oleifera against breast cancer via molecular docking, pharmacokinetic parameters, and drug-like properties. The result shows that rutin, vicenin-2, and quercetin-3-O-glucoside have the highest binding energy of −7.522, −6.808, and −6.635 kcal/mol, respectively, in the active site of BRCA-1. The essential amino acids involved in the protein-ligand interaction following active site analysis are ASN 1678, ASN 1774, GLY 1656, LEU 1657, GLN 1779, LYS 1702, SER 1655, PHE 1662, ARG 1699, GLU 1698, and VAL 1654. Thus, we propose that bioactive compounds from M oleifera may be potential novel drug candidates in the treatment of breast cancer.
2006 · Sokoto Educational Review · 18 citations
EFFECT OF COMPUTER-ASSISTED INSTRUCTION AND SIMULATION/GAMES ON THE ACADEMIC ACHIEVEMENT OF SECONDARY SCHOOL STUDENTS IN BIOLOGY
This study investigated the effect of Computer Assisted Instruction (CAI), Simulation/Games and Conventional Methods on the academic achievement of students in Biology. The treatment at the three levels of CAI, Simulation/Games and Conventional Method was crossed with gender at the two levels of male and female, and locus of control, at the two levels of internals and externals. Data analysis involved Analysis of Covariance as well as Multiple Classification Analysis as a post-hoc measure. The findings revealed no significant two-way and three-way interactions of treatment and gender and locus of control. However, there were significant main effects of treatment and locus of control on students’ achievement in Biology. The MCA further revealed that students taught with the Computer-Assisted Instruction achieved highest while students taught with Simulation/Games achieved better and those students taught with the Conventional Method had the lowest adjusted post-test mean score. Based on these findings, the use of Computer Instruction and Simulation/Games are recommended for teachers in Biology classrooms irrespective of the students’ gender and locus of control. The government is further enjoined to provide computers, programs, instructional packages, costumes and enabling environment for the use of these instructional strategies in schools.